A Santana cruise sounds good, but actually turned out to be an experience I regret completely. Bill, the owner/operator, is extremely disorganized, rude and dishonest. Planning the trip was tense because he won't reveal the names of the hotels at the beginning or the end of the trip (so that he can book it and get a commission). This makes planning to get into town early or stay later at the end nearly impossible. His communications are full of irrelevant statements and patronizing (telling you how to use basic technology, for example). He's also quite misogynic so if you're a single female rider I suggest avoiding this company. Everything is geared to the males in the group (free jersey for the men; women make due because it's too expensive to offer jerseys that fit both sexes).
If you choose to go, get the very very best trip insurance and be aware. Better yet, just pick a different company.